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For a large number of patients, some type of long-term maintenance therapy is clinically indicated to continuously manage their chronic metabolic disease, much like traditional blood pressure care, cholesterol management or many other health programs

However, there has been relatively limited exploration of the role of gut microorganisms in inhibiting endogenous GLP-1, with many studies conducted using in vitro models

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These findings suggest that pancreatic 5-HT plays an important role in insulin secretion by acting on different 5-HT receptors expressed on different cell types