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Last reviewed: June 8, 2026 Last updated: June 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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When treatment is titrated toward weight loss rather than glycemic control, average reductions can be much larger, with a trial-level result of 14.9% body weight loss over 68 weeks under a weight-focused escalation protocol

B cells produce antibodies that interfere with cardiomyocyte function, recruit a variety of immune cells, and play an important role in heart failure [102]