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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of IDH1 and IDH2, changes in glutaminolysis that deplete KG, or alterations in fumarate hydratase (FH) and succinate dehydrogenase (SDH) that inhibit KGDD activity (Losman et al., 2020)

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When I originally looked at the 120 first biotech companies in this sector, it was very clear that there were more located and based in the San Francisco Bay Area than any other major metropolitan area in the world by a factor of two