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Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

According to the several studies conducted with different instrumental techniques, such as by Nuclear Magnetic Resonance ( 113 Cd-NMR [152]), X-ray diffraction, and molecular mechanics and dynamics calculations [153], metallated metallothioneins look like protein chains wrapped around a metal cluster, with multiple cysteines liganding metals through their thiolate groups [154], as exemplified in Scheme 13 for the tetra-metallated domain of a Cd-loaded MT

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