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78 Perhaps due to the attention paid to APAP-induced acute liver failure, survival rates of 60% are touted as decent when compared to DILI from other substances.77 New research in detecting biomarkers of injured and necrotic hepatocytes seems promising, especially since it has become increasingly important to identify APAP-induced acute liver injury patients earlier in order to provide lifesaving medical and surgical therapies

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GSDMD has the ability to bind lipid and form protein pores on cell membranes, leading to plasma membrane rupture, cell swelling, release of intracellular substances including IL-1 and IL-18, and eventually cell death [6]