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Secondary analyses included 442 patients without NAION, and the risk of NAION was consistently higher in the semaglutide cohort
Its mechanism can be summarized as: Activation of the GHRH receptor cAMP/PKA signaling inside pituitary somatotrophs Endogenous growth hormone release Downstream IGF-1 pathway activation DAC-dependent differences in duration and exposure Importantly, CJC-1295 is not growth hormone
Most first timers on the 2 mg starting dose have a quiet, uneventful first month, which is exactly the point of starting low
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