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Necroptosis Engagement of TNF superfamily receptors, toll-like receptors (mainly TLR3 and TLR4), and interferon receptors drives the process of necroptosis during which the interaction between receptor-interacting protein kinase 1 (RIPK1) and RIPK3 leads in formation of heterodimer complex that promotes oligomerization of mixed-lineage kinase domain-like protein (MLKL)acts as the RIPK3 substratethrough phosphorylation

10.3390/nu16244296 291 TianK.-M.LiJ.-J.XuS.-W