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Furthermore, AgRP neurons send potent inhibitory projections [via gamma-aminobutyric acid (GABA)] directly onto POMC neurons, providing a second, parallel mechanism to suppress satiety signaling and promote a robust orexigenic drive [11]

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This persistent risk has been attributed to additional factors, such as triglyceride-rich lipoproteins, remnant cholesterol, lipoprotein(a), and chronic inflammation

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