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Description

Lane HY, Chang YC, Liu YC, Chiu CC, Tsai GE

Currently, known 11-HSD1 inhibitors can be categorized into two primary groups: natural inhibitors and chemically synthesized inhibitors

In addition, PYC suppresses adipose differentiation-related protein, which is involved in atherosclerosis development and highly expressed in macrophages (Gu et al., 2008), by inhibiting activator protein-1 (AP-1) and NF-B activities, thereby reducing atherosclerosis (Gu et al., 2008)