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Since GLP-1 and GLP-1RAs can interfere with IGF-1 signaling by modulating IGF-1R expression [10], [11] and interacting with IGF-1R [13], we hypothesized that semaglutide-treated LPD mice could develop a resistance to IGF-1 in addition to their resistance to GH, which could explain their hampered growth

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Discussion In this cohort study of patients with advanced DKD, we evaluated the associations between cardiovascular and kidney outcomes in patients with GLP-1RAs versus DPP-4is