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Additionally, no new nanomedicines have been approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA) for RA between 2023 and 2025, highlighting significant gaps in translating laboratory innovations into clinical practice (54)

Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, et al

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Furthermore, neuroimaging studies have shown significant decreases in hippocampal volume among depressed patients, correlating these anatomical changes with the severity of depressive symptoms and cognitive dysfunction [20,21]