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Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations

Studies have explored its role in: Angiogenesis: The formation of new blood vessels, a critical process for healing damaged tissue

gingivalis -triggered proinflammatory alveolar bone destruction in vivo and RANKL-associated osteoclasts development, stimulation, and metabolism in vitro (Gu et al., 2019)