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This paper was supported by the National Key Research and Development Program of China (2022YFD1300100), China Agriculture Research System of MOF and MARA (CARS-40), the Supports High Quality Development of Seed Industry Fund Project of Hubei Province (HBZY2023B007), Hubei Agricultural Science and Technology Innovation Center Project (2025-620-000-001-015)

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Important considerations for in-use storage: Remove needles after each injection Never store pens with needles attached, as this can cause air bubbles, medication leakage, or needle blockage Avoid direct sunlight and heat sources Keep pens away from windowsills, radiators, and direct sunlight Follow product-specific guidance on re-refrigeration Some products should not be re-refrigerated once brought to room temperature, while others can be Write the date of first use on the pen label to track the in-use expiry period Always consult the patient information leaflet specific to your prescribed GLP-1 medication, as requirements differ between formulations

The rates of prevention for preeclampsia, pregnancy-induced hypertension, and GDM were 92.7%, 92.8%, and 99.2%, respectively, compared with any other treatment or placebo (Kalafat et al., 2018)