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In another exploratory analysis of SURPASS-3 MRI, comparing SURPASS-3 participants with sex- and body mass index-matched virtual control groups, treatment with tirzepatide was related to reduced liver fat content and VAT, but abdominal subcutaneous adipose tissue increased at week 52 among participants from the SURPASS-3 MRI substudy [89]

Additionally, as described above, ~60% of peak LAG-1 accumulation is GLP-1 dependent, about 50% of which can be attributed to lst-1 and sygl-1 activity

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