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The most critical period for damage appears to be during the first trimester, resulting in birth defects affecting the cardiovascular system, central nervous system, facial area, and thymus (an organ involved in immune cell production)

Retrieved May 27, 2025, from Centers for Disease Control and Prevention

We previously showed that HTH treatment caused the translocation of gut bacterial and elevated intestinal TNF- levels 6 , which has been related to impaired GLP-1 expression and secretion 11