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Aged mice also have hallmarks of BBB breakdown compared to young mice with increased leakage of IgG into the brain parenchyma, a reduction of the tight junction protein occludin, and a reduction in pericyte coverage and pericyte induced expression of genes in the endothelium [54, 90, 91]

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The study showed that the odds ratio for liver cirrhosis tend to decrease from 1.0 for people abstaining from coffee to 0.47, 0.23, 0.21, and 0.16 for 1, 2, 3, or 4 cups of coffee daily, respectively