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When to stop Discontinue and seek medical attention if you experience: severe abdominal pain that does not resolve, persistent vomiting, signs of pancreatitis, changes in vision, or any allergic reaction (difficulty breathing, swelling of face or throat)

It makes more sense when you tie it to the gut barrier and immune reactions

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Ongoing waves of SARS-CoV-2 infection sustain the scenario where in the absence of improved vaccines or immunotherapies, clinically vulnerable individuals will still require annual or biannual vaccinations with updated immunogens matched to circulating variants